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Drug Treatment In this study, we used FOXO4 D-Retro-Inverso peptide (FOXO4-DRI, NovoPro, Shanghai, China) and ABT-263 (Apexbio Technology, Houston, TX, United States) to selectively remove the senescent chondrocytes

Step-therapy denials require either documenting the trial of the required alternative or appealing on clinical grounds (the alternative is contraindicated, has been tried unsuccessfully, or is inappropriate for a documented reason)

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